Maitake's therapeutic potential has been researched intensively since the late 1970s. Below is a list of the main targets of this research*.
Due to legal restrictions we can't give more details. Our research section has several interesting publications, free to download.
Before you start using Google for more information, read the section at the bottom: 'Why choose ORIVeDA's Grifolan ?'
• Maitake's anti-viral and anti-tumor potential (in vivo, in vitro and clinical tests)
• Maitake's cardiovascular effects
• The effect on the Chronic fatigue syndrome (CFS)
• General balancing of the immune system. Maitake is considered 'King of Immunity'
• The effect on diabetes. Maitake contains a natural alpha glucosidase inhibitor, which lowers blood sugar
• Blood pressure regulation
• Anti-cancer adjuvant - using purified Maitake extracts together with regular treatment seemed to improve the effects considerably.
In all the literature (and this is a lot!) no side effects or any signs of toxicity were reported. Even in very high doses no differences in heart rate, temperature, metabolism and general physical condition were found.
Because Maitake has immune-balancing properties, it should not be used together with immune-suppressants, like those prescribed after a transplant.
Maitake can cause swings in blood sugar. This can cause temporary fatigue in those that are highly susceptible. In general these people are also very susceptible to e.g. caffeine and alcohol, or are diabetics. Taking the extract together with a sugar containing liquid can neutralise this effect.
When you use Google to look for additional details on Maitake's therapeutic potential you will read about the 'D-Fraction®*
', the 'MD-Fraction' and others.
The d-fraction is originally a term coined in the 1980s; it referred then to a purified -fractionated-
beta-glucan, bonded with a protein; a so-called 'proteoglycan'. This particular fraction showed a lot of promise because of its anti-tumor potential.
Unfortunately, neither this product nor its successor, the md-fraction (a more pure version of the d-fraction, patented in 1997)
is for sale in its undiluted pure form; the production costs are too high (it's a 200 : 1 extract)
and the fractionating process is too complex for mass-production.
Although the manufacturers prefer to keep the details as vague as possible (marketing reasons)
, here are some -verifiable-
Apart from being a research-term, 'D-Fraction®' is also a trademark*, registered in 1995. Products sold with the name 'D-Fraction®' contain, according to the label 'PD-Fraction®*' (which stands for 'Pre-D-Fraction'). It is unclear what this is.
The commercial 'D-Fraction®' has been tested against another Maitake extract, MaitakeGold 404®* (MTG), containing (according to that same test rapport and a follow-up) a diluted version of the md-fraction. The test involved many immunological parameters. MTG scored significantly better in all tests.
MTG is standardised for ≥ 20% (1>3)(1>6)beta-glucans (though not on the label; only in B2B communication). Nothing else.
The glucan/protein ratio is not revealed, although this would be an easy and cheap way to authenticate the product as being pure (the ratio should be between ± 2 : 1 (= d-fraction purity) all the way to 99 : 1 (= md-fraction purity) according to the patents).
MTG is sold only in liquid form; 1 gram of extract dissolved in 30 ml of liquid. The recommended daily dosage is 8 - 16 drops daily, which equals 19 - 77 mg MTG.
The optimal dosage of this extract is, according to independent research (a clinical trial), 7 mg/kg bodyweight/day (e.g. a 60 kg person should take ± 420mg daily), which is significantly more.
ORIVeDA's Grifolan is standarised for ≥ 30 % (1>3)(1>6)beta-glucans, has a glucan/protein ratio of 2.06 : 1 (similar to the original d-fraction) and can deliver the recommended daily dosage easily. Because the extract used in the research was more pure than any commercially available product, the dosage should be adjusted accordingly: we recommend 4 - 8 sachets per day (each with ≥ 300 mg beta-glucans) if maximum therapeutic potential is needed.
, based on the known facts we feel confident ORIVeDA Grifolan® is at least equal to, if not more potent than any of the current commercially available Maitake products. Apart from that, the value for money is much better.
A 100% pure product with natural vitamin C. Vitamin C has a synergistic effect together with Maitake. It also improves the bioavailability of the bioactives.
Certified and produced in compliance with ISO 9001:2008, GMP, HACCP.
*D-Fraction® and PD-Fraction® are trademarks of Mushroom Wisdom, Inc., NJ, USA. MaitakeGold 404® (MTG) is a trademark of The Tradeworks Group, VT, USA
Grifola frondosa, Maitake, anti-diabetic, anti-cancer adjuvant, anti-cholesterol, Grifolan, immune support, anti-viral, anti-cancer